Short-term storage can be done at 4C, while long-term storage can be done by freezing at -20C or -80C, or by lyophilization. It is always advisable to carefully read them before trying to reconstitute the peptides. With a deluxe kit, you will have all you need for safe injections at your disposal. Benzyl alcohol can be a topical irritant but in the concentration of 0.9% does not typically cause irritation and may provide some anesthetic effects. The action you just performed triggered the security solution. We spent 20 hours of research finding optimal recommended dosages for every popular peptide. Your Content must be your own and must not be invading any third-partys rights. Using Bacteriostatic Water vs. Sterile Water - Paradigm Peptides The second step is to use your syringe and draw out 1ml of bacteriostatic water from the vial without really touching the needle as it could cause contamination. Your best option for assembling the necessary tool kit is a single, reputable source. The process of reconstitution is the same regardless of what kind of water you chose to reconstitute your AOD with. When you buy through links on our site, we may earn a commission. Using the 28-29 gauge insulin syringe, you will have to draw 0.1 ml of water per injection. Because they are antibiotics, low bioburden of these formulations would be expected at the time of batching. 5.0 out of 5 stars Good product. 29-31, 48; 1986. While there is not a long-term shortage, an acute shortage is often seen because of either manufacturing facilities malfunction or some medical emergency such as COVID-19. Due to the potential for toxicity, solutions containing benzyl alcohol should not be used in neonates. SIDE EFFECTS. What is the difference between bacteriostatic water and sterile water Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) of benzyl alcohol added as a bacteriostatic preservative. The primary uses of bacteriostatic water are as follows: When using bacteriostatic water for injections, certain precautions must be followed. The filling of vials that are to be lyophilized has some problems that are somewhat unique. Plus, it is a great dilutant for a range of drugs and therapeutic substances, facilitating aqueous delivery without compromising potency or effectiveness. Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. From medications to peptides and hormones, bacteriostatic water is a winning option when it comes to reconstitution and sterility. Its like a chemistry experiment, but instead of blowing things up, youll be improving your health. Acidic peptides will be best soluble in basic solution and vice versa. and ADVERSE REACTIONS. Use aseptic technique for single or multiple entry and withdrawal from all containers. As I mentioned at the start, the sterile water vial doesnt contain benzyl alcohol which makes it unfavorable for storage. A verification code will be sent to you. Reconstituted peptides can be stored in several ways, depending on the duration of storage and the desired shelf life. The contents of Peptides.org are intended exclusively for qualified researchers. The pH is 5.7 (4.5 to 7.0). As it cannot transfer pathogens, it is used mainly used in the medical field. By displaying Your Content, you grant Buckle LLC a non-exclusive, worldwide irrevocable, sub licensable license to use, reproduce, adapt, publish, translate and distribute it in any and all media. The pH is 5.7 (4.5 to 7.0). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It is essential to avoid repeated freeze-thaw cycles and exposure to light and high temperatures. The safety and effectiveness of Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP have not been established in pediatric patients. Buckle LLC reserves the right to remove any of Your Content from this Website at any time without notice. Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Click to reveal It depends on the compound, there is no universal conversion, About: Muscle and Brawn is a coaching company specializing in bodybuilding, hormones, peptides, anabolics, and other biohacking. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, . Bacteriostatic Water for Injection Prescribing Information. This parenteral preparation is unlikely to These two solutions are sterile water and bacteriostatic water. That means, they are single-dose vials and should be discarded after a single-use. Do not agitate the solution, which can damage the peptides. To make it easy for you to get the best materials, the Peptides.org team has perused the web and selected the single best online source for your injection material requirements: This trusted vendor has an impressive selection of full research kits for your convenience. These Terms will be applied fully and affect to your use of this Website. So, if you want to maximize the efficacy of your peptides, follow our guide step-by-step, and soon youll be a reconstitution pro. With patients having the autonomy to take medications at home at their own comfort, the education on these sterile solutions is crucial. Lyophilization of Parenterals | FDA Bacteriostatic 0.9% Sodium Chloride (NaCl) Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP containing additives should be given to a pregnant woman only if clearly needed. Store at 20 to 25C (68 to 77F). It is also not known whether Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection containing additives can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Their pH levels and chemistry are distinct. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Although rarely, but they can occur, those side effects are more related to the drug that is dissolved in the bacteriostatic water. This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. If you are a peptide researcher or laboratory professional, you can safely enjoy the benefits of bacteriostatic water with proper use. Patients, athletes, healthcare workers and others use sterile solutions to help in medication delivery, injections, irrigation and other uses. On the other hand, if the peptide vial has been reconstituted, make sure that you store it between 2 and 8 degrees celsius because the reconstituted peptides are susceptible to minor temperature changes. Bacteriostatic water has wider availability and is simpler to manufacture. Once vials are partially stoppered, they are transported to the lyophilizer. We strive to never have a piece of inaccurate information on this website. For the reconstitution of HGH powder, bacteriostatic water is a great choice, as it preserves HGH solutions and efficiently dissolves lyophilized aggregates [16]. Bacteriostatic water formulations for injection have pH levels of 4.5-7, averaging 5.7. There is literally no other option. So it all differs and the exact dosage can only be prescribed by your health practitioner. Both sterile solutions are formulated for medical use. Peptide Reconstitution: Dosing, Mixing and Storage Guidelines This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. As the recommended dosage is 500mcg, dividing the total of 5000mcg by 500mcg will yield 10 injections per BPC 157 vial. Bacteriostatic water works well as a peptide solvent, reconstituting the compounds without compromising their effectiveness. Daptomycin: a comparison of two intravenous formulations Follow medical advice and relevant indications for maximum safety and results when using bacteriostatic water for injections. Remove Advertising. This solution has no antimicrobial agents. However, if you can get your hands on some, then congratulations, youre already ahead of the game! Obviously, there is a much greater chance of contamination in this type of operation because of the involvement of people. Cookie Notice Other side effects from bacteriostatic water have been reported to include tissue death, venous thrombosis, infection at the injection site, fever, abscess formation as well as a febrile response. Lysis is the breaking down of a cell or membrane. We partner major pharmaceutical companies in India & abroad as a reliable and efficient contract manufacturer. Our focus is to exclusively link to peer-reviewed studies found on respected websites, like PubMed. Made with the organic preservative benzyl alcohol, this solution resists contamination to enable multiple doses per vial. You will learn its various applications, how it differs from sterile water, and your best online source to buy bacteriostatic water kits. It is a copolymer of ethylene and propylene. After that, collect and prep your materials. If symptoms appear, injections should be discontinued pending medical consultation [9]. Once you open the seal of the sterile water vial, you will either have to use it preferably within the next 4 hours or discard it. As mentioned previously, sterile water only has distilled water and nothing else. Medications that required diluting with water usually indicate on the bottle which water is preferred for use. Please refer to the WARNINGS Using either in the proper conditions can provide extraordinary results. Bacteriostatic Water for Injection, USP containing additives should be given to a pregnant woman only if clearly needed. Typically available as lyophilized powders to maintain purity and integrity, peptides require reconstitution before injection [12]. Note that you cant administer bacteriostatic water into your body without diluting it with any medication as the benzyl alcohol could trigger adverse cellular reactions into your body. Sterile water usually comes in single-unit doses and the reuse of units is prohibited. Lyophilized peptides are considerably stable at room temperature, so if you dont want to reconstitute the lyophilized peptide for some time, dont worry and just keep it a room temperature. Always use as directed on the label. Morgan, SL and Spotts, MR; "How to Select a Pharmaceutical Freeze-Drying System"; Pharmaceutical Technology, volume 3, No. Methylprednisolone sodium succinate has the same . For intravenous or intramuscular injection, prepare solution by aseptically adding not more than 2 mL of Bacteriostatic Water for Injection or Bacteriostatic Sodium Chloride Injection to the contents of one vial. More posts from r/Peptides 46K subscribers Hour_Love5645 6 days ago NSFW Complement your research with this USP solvent, the go-to solution of the medical and scientific community. Once you have put the details, our reconstitution calculator will use its algorithm and devise the volume needed to get your peptides reconstituted! Made with Muscle. Should I dilute with sterile water (USP grade) or BW? Bacteriostatic water should not be used on individuals with benzyl alcohol allergies. Bacteriostatic Water It is only used for injections such as intravenous, intramuscular and subcutaneous. Injections are best suited to fatty areas, such as the thigh or waist. These are the primary similarities between bacteriostatic water and sterile water [5]: Here are the key differences between bacteriostatic water and sterile water [5]: Despite their similarities, bacteriostatic water and sterile water differ in a few key areas. Be sure to consult indications for exact dosage and concentration. Another method of sterilization that has been practiced is the use of gaseous ethylene oxide. Additionally, stability data should include provisions for the assay of aged samples and subsequent reconstitution of these aged samples for the maximum amount of time specified in the labeling. Leucovorin Calcium - GlobalRPH Do not use unless the solution is clear and seal intact. Contact us at info@Bacteriostaticwater.com, Bacteriostatic Water vs. Sterile Water: The Differences That Can Save Your Life. The pH is 5.7 (4.5 to 7.0). Yes, distilled water can also be used to reconstitute peptides alongside the bacteriostatic and sterile water. For safe storage, adhere to manufacturer indications. Drug class: Sterile irrigating solutions. Buckle LLC is permitted to revise these Terms at any time as it sees fit, and by using this Website you are expected to review these Terms on a regular basis. It is recognized that there is complex technology associated with the manufacture and control of a lyophilized pharmaceutical dosage form. The next and immediate step is to add the water you have drawn out into the peptide vial slowly yet smoothly. The container requires no vapor barrier to maintain the proper labeled volume. Drop us a comment down below and one of our expert coaches will respond to it, you can also email is at coaching@muscleandbrawn.com. Haven't had any problems with this bacteriostatic water. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. When the lyophilized product does not include an excipient or other additive and only represents the active ingredient, weight variation can be employed as the means to test for dose uniformity. Sterile water is available for injection use such as intravenous, intramuscular and subcutaneous. 62.5 mg/mL, 3.2 mL b. However, there are some differences between the two. You should never inject bacteriostatic water without mixing in any medications because the benzyl alcohol in it causes the red blood cell lysis. Wir bieten unseren Kunden mit ntzlichen Informationen und Ratschlge, die sie bentigen, fundierte Entscheidungen zu treffen, ihre Ziele zu erreichen. However, this method requires special equipment and expertise. Bacteriostatic Water for Injection, USP is supplied in a multiple-dose 30 mL plastic fliptop vial (List No. Provisions for sterilizing and assuring the integrity of vent filters or filters used to sterilize the inert gas and air. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Where water is required for preparing or diluting medications for use in neonates, only preservative-free Sterile Water for Injection should be used. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. For more information, please see our PHARM TEST #2: Reconstitution Flashcards | Quizlet How to Properly Mix, Dose, and Store Peptides - Paradigm Peptides Need to know how much to buy. If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate countermeasures, and if possible, retrieve and save the remainder of the unused vehicle for examination. The benzyl alcohol in it would cause red blood cell lysis. Generally lyophilized products have short expiration dates. Any individual seeking any advice on any prescription medication, or any disease or condition, is advised to refrain from using this site and consult their healthcare provider. I recommend using bacteriostatic water since that's what the peptide vendors sell and recommend. Overdose & Contraindications OVERDOSE Use only as a diluent or solvent. Reconstitution. Example would be 5g of CJC-1295 and 5g of ipamorelin. Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Once a vial of sterile water is open, it should be used completely at once or used once and discarded. Although both of these types of water are sterile, the difference between bacteriostatic water and sterile water is that other sterile waters for injection do not contain a bacteriostatic agent. 4 people found this helpful. The re-use of sterile water for injections is strictly prohibited. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. All of our content is written by people with a strong science background, including medical researchers. The action you just performed triggered the security solution. What you should be doing is drip the water onto the inner surface of the vial so that there is enough time for the lyophilized peptide and water to mix. Slowly extract the bacteriostatic water until the solution reaches your desired level. Administration of an estimated 9 mL to a 6 kg infant or neonate is potentially capable of producing blood pressure changes. and discoloration prior to administration, whenever solution and container permit. The process is simple. 3) Choose the size of the syringe you want . According to a recent study, 99.9% of people struggle with this step. It is not intended nor implied to be a substitute for professional medical advice. Note that sodium chloride water shouldnt be used as it may result in precipitates. There are only two kinds of water that are most safe to reconstitute peptides. Due to the pH, a more apt solution for fluid replacement is normal saline or dextrose. Lets just assume that you have been prescribed 500mcg of BPC 157. The most common side effects of H2Oinclude: Tell the doctor if you have any side effect that bothers you or that does not go away. Both bacteriostatic water and sterile water are not used for straight injections, they have to be diluted with a drug or solvent. A major concern with the filling operation is assurance of fill volumes. The starter set has all you need to get going, including the following: If you want a little more, check out the premium kit: Qualified handlers are sure to enjoy this top online source for research materials. Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). New comments cannot be posted and votes cannot be cast. Bacteriostatic water differs from sterile water by the addition of benzyl alcohol as a preservative with a final concentration of 0.9%. RxList does not provide medical advice, diagnosis or treatment. Two sterile solutions that are commonly used are bacteriostatic water and sterile water. HCG solutions are to be refrigerated to prevent degradation [19]. It is used as a solvent or dilutant for drugs or therapeutic compounds that call for aqueous injection. Once the peptide is really made soluble in any of the relevant solutions, diluting it with bacteriostatic water or sterile water is recommended. These include subcutaneous, intramuscular, intravenous, and intradermal injection routes [. I have this same question. You may be surprised to learn that they are not interchangeable [5]. Bacteriostatic Water belongs to a class of drugs called Sterile Irrigating Solutions. Bacteriostatic Water for Injection, USP must be made approximately isotonic prior to use. Curious about Bacteriostatic Water for injections? PDF Zomacton Description In a nutshell, in order to make the 1 proper dosage of BPC-157, you would need to draw 10 units of water and then mix it by following the reconstitution guidelines. This monograph has been modified to include the generic and brand name in many instances. They quickly get ruined by heating, even room temperatures, and vigorous movement. How to use reconstitute in a sentence. Parenteral preparations containing benzyl alcohol should not be used in epidural or spinal anesthesia procedures. This bacteriostat is usually 0.9% benzyl alcohol. HGH Mixing Reconstitution 1. The packaged diluent (Bacteriostatic Water for Injection) contains benzyl alcohol as a preservative. Distilled water is a form of sterile water but sterile water is not always distilled! If an adverse reaction does occur, discontinue the infusion, evaluate . Because many of the types of products are antibiotics, subpotency in a vial can present a potentially very serious situation. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. It also is prepared with a bacteriostat, a compound used to prevent any bacterial growth. Wipe down all materials with an alcohol swab. But dont get too excited just yet. Due to the bacteriostat, bacteriostatic water comes in a multi-dose formulation for multiple uses. This guide will explore key information on the use of bacteriostatic water for injections. Report. Long-term storage: For long-term storage, it is recommended to aliquot the reconstituted peptide into small volumes and freeze them at -20C or -80C. Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. Reconstitution Solution versus Bacteriostatic Water I need to rehydrate some BPC, but when I look for bacteriostatic water on Amazon, it takes me directly to "reconstitution solution." If both items are the same (benzyl alcohol bacteriostatic solutions) why use the different name? It could be potentially harmful to try to reconstitute a peptide meant for mixing with bacteriostatic water with sterile water. Both act as dilutants or solvents of substances to enable injection. Bacteriostatic Water may be used alone or with other medications. Scan this QR code to download the app now. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Handlers should follow the applicable dosage and administration schedule [16]. Unused vials can remain viable for years with proper storage [4]. You use Bac.Water to backload the pin. Due to the potential toxicity of benzyl alcohol in neonates, solutions containing benzyl alcohol must not be used in this patient population. Based on 31 documents. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection.